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The Iron & Autoimmunity Connection.

autoimmune autoimmune disease iron

One of the most common issues I see in my practice is autoɪmmunity. And after doing a little bit of lab testing, it’s not uncommon for me to see low bioavailable Copper and excess Iron.

This could potentially have to with the fact that excess Iron can turn on the “danger signal” of the body, called the NLRP3 inflammasome. (Nakamura et al)

NLRP3 is part of the ɪnnate ɪmmune system. When it gets turned on, it releases proteins like cyt0kines, chem0kines and other acute phase proteins that respond to inflammation, damaged or ɪnfected tissue, etc.

Excess Iron gets sequestered in our tissues and organs to our body’s best abilities. But this mechanism has its limits too.

Until we have regained the ability to properly manage Iron, it’s not unreasonable to think that the NLRP3 inflammasome could stay turned on. This constant “on” switch could cause overactivity, possibly eventually leading to autoɪmmunite dise@se.

Now of course, the topic of autoɪmmunity can be farrr more complex than this. And everyone’s experience is different. The reason I bring up Iron is because it’s usually one of the factors I personally see involved in those clients dealing with it.

One of my favorite tools that can provide insight into someone’s Iron metabolism is the Full Monty Iron Panel, which I’ll be talking about more in the future.

If you’re hungry for more info on Iron, you can check out my highlight called ‘Iron & Copper’ or go straight to The Root Cause Protocol’s website.

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Not Medical Advice.

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This is not medical advice. Always consult your healthcare professional before pursuing any changes to your personal healthcare regime.

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References

Kelley, N. Jeltema, D. Duan, Y. He, Y. (2019). The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation. Retrieved from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651423/#:~:text=The%20NLRP3%20inflammasome%20is%20activated,shown%20to%20trigger%20its%20activation.

Nakamura, K. Kawakami, T. Yamamoto, N. Tomizawa, M. Fujiwara, T. Ishii, T. Harigae, H. Ogasawara, K. (2015). Activation of the NLRP3 inflammasome by cellular labile iron. Retrieved from: https://www.exphem.org/article/S0301-472X(15)00730-4/pdf.

Robbins, M. (2017). Iron Toxicity Post #59: A Tale of two irons and the hepcidin peptide that regulates them. Retrieved from: https://therootcauseprotocol.com/iron-toxicity-59-a-tale-of-two-irons-the-hepcidin-peptide-that-regulates-them-causes-chaos-confusion-clinical-conditions-clinical-currency/.

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Remember: this post is for informational purposes only and may not be the best fit for you and your personal situation. It shall not be construed as medical advice. The information and education provided here is not intended or implied to supplement or replace professional medical treatment, advice, and/or diagnosis. Always check with your own physician or medical professional before trying or implementing any information read here. While the owner of this website tries to keep the information up to date, there may be things that are out-of-date and out of their control.