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Polyunsaturated Fatty Acids (PUFAs) Behave Like Estrogen in the Body

estrogen estrogen dominance pufas

We live in a PUFA-laden and estrogen dominant-world, baby. Think they’re connected? They sure are.
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Polyunsaturated fats (PUFAs) are estrogenic, which means that they act the way estrogen does, causing cells to uptake water and multiply at a rapid rate.
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“The estrogen-promoting actions of soy oil apply to all of the commonly used polyunsaturated fatty acids. The same fatty acids that suppress thyroid function, have estrogenic effects.”
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Both estrogen and PUFA potentiate (increase) each other to boot.
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“The accumulation of the “essential fatty acids,” the polyunsaturated oils, in the tissues promotes the action of estrogen in a variety of ways, and this effect of diet tends to be cumulative, and to be self-accelerating.”
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Estrogen and PUFAs are both excitotoxic, meaning they cause the overactivity of excitatory neurotransmitters, which can damage and kill nerves.
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And it’s not just plant-based PUFAs. “The growth and metastasis of a variety of tumors are inhibited by saturated fatty acids, and increased by fish oil--as much as 10 times in number of metastases, 1000 times in size.”
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Estrogens and PUFAs are so potent that “puberty occurs at an earlier age if estrogen is high, or if these oils are more abundant in the diet.”
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What am I trying to get at?
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While it’s impossible to have a diet completely void of PUFA, if you or someone you know is struggling hormonally and metabolically, it may be beneficial to minimize consumption.
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SO:
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Minimize use of PUFAs like canola, cottonseed, corn, soy, safflower, flax, peanut, sesame, vegetable, etc.
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Minimize foods that contain them like mayo and processed foods — check the ingredient label!
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Limit consumption of excess legumes, nuts, seeds and grains, which all have estrogenic effects too
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Go for organic, grass-fed and pasture-raised when possible — otherwise animals are usually fed corn and soy, which inherently increased PUFA content
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Rethink that fish oil supplement
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Prioritize saturated fats like butter, tallow and ghee
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Consider a high-quality Vitamin E supplement like @mitolife, which can be protective against estrogen and PUFA
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All quotes by Dr. Ray Peat
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Not medical advice.

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This is not medical advice. Always consult your healthcare professional before pursuing any changes to your personal healthcare regime.

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References

Griffini, P. Fehres, O. Klieverik, L. Vogels, I.M. Tigchelaar, W. Smorenburg, S.M. Van Noorden, C.J. (1998). Dietary omega-3 polyunsaturated fatty acids promote colon carcinoma metastasis in rat liver. Retrieved from: https://pubmed.ncbi.nlm.nih.gov/9699661/.

Peat, R. (2006). Unsaturated Vegetable Oils: Toxic. Retrieved from: http://raypeat.com/articles/articles/natural-estrogens.shtml.

Peat, R. (2007). Unsaturated fatty acids: Nutritionally essential or toxic?. Retrieved from: https://raypeat.com/articles/articles/unsaturatedfats.shtml.

Peat, R. (2008). Natural Estrogens. Retrieved from: http://raypeat.com/articles/articles/natural-estrogens.shtml.

Peat, R. (2013). Fats, functions and malfunctions. Retrieved from: http://raypeat.com/articles/articles/fats-functions-malfunctions.shtml.

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Remember: this post is for informational purposes only and may not be the best fit for you and your personal situation. It shall not be construed as medical advice. The information and education provided here is not intended or implied to supplement or replace professional medical treatment, advice, and/or diagnosis. Always check with your own physician or medical professional before trying or implementing any information read here. While the owner of this website tries to keep the information up to date, there may be things that are out-of-date and out of their control.